Prospero Phase-Separating the Way to Neuronal Differentiation
نویسندگان
چکیده
منابع مشابه
Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS.
In many organisms, single neural stem cells can generate both neurons and glia. How are these different cell types produced from a common precursor? In Drosophila, glial cells missing (gcm) is necessary and sufficient to induce glial development in the CNS. gcm mRNA has been reported to be asymmetrically localized to daughter cells during precursor cell division, allowing the daughter cell to p...
متن کاملBiochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero.
Drosophila neuroblasts are a model system for studying asymmetric cell division. Neuroblasts bud off a series of smaller progeny, called ganglion mother cells (GMCs). An essential regulator of GMC development is the Prospero homeodomain transcription factor: Prospero is asymmetrically localized to the basal cortex of the mitotic neuroblast and partitioned into the newborn GMC. Prospero is trans...
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We study a dynamical model of a system with two disparate energy scales, and focus on the kinetics of phase separation. In this model, nearest-neighbor monomers can interact with one of two quite distinct energies, thereby describing a system with, e.g. , van der Waals and hydrogen bond interactions. While the model has been described by an efFective Ising model in equilibrium, the nonequilibri...
متن کاملThe origin of Prospero
Context. It is widely accepted that the large obliquity of Uranus is the result of a great tangential collision (GC) with an Earth size proto-planet at the end of the accretion process. The impulse imparted by the GC affected the Uranian satellite system. Nine irregular satellites (irregulars) have been discovered around Uranus. Their orbital and physical properties, in particular those of the ...
متن کاملEffect of Different Doses of Staurosporine For Neuronal Differentiation
Purpose: The present study was designed to investigate the effect of different doses of Staurosporine on differentiation of PC-12 cell line into differentiated neuronal cells. Materials and Methods: PC-12 cell line as a useful model system for neurobiological studies was maintained in RPMI 1640 supplemented with 10% FBS. Staurosporine were added to culture medium in different concentrations (1...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2020
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2020.01.022